With the fall of the Assad government threatening Iran's key strategic foothold in the Levant, Tehran signals an interest in forging ties with Syria's new power holders, according to an Iranian official.

Long-time President Bashar al Assad fled the country at the weekend, leaving a vacuum in the country after both Iran and Russia had since 2011’s civil war, supported.

Reuters reported that talks had begun in an attempt to "prevent a hostile trajectory" between the countries after a rapid takeover saw the 50-year Assad family rule collapse in days.

The senior official told Reuters that Iran's clerical rulers, facing the loss of an important ally in Damascus and the return of Donald Trump to the white House in January, were open to engaging with Syria's new leaders.

Iran had multiple military bases across Syria, having controlled airports and sea ports which have been a key smuggling route to Iran’s military allies in the region, including its largest, Hezbollah in Lebanon. It is not clear if there is an Iranian presence left in Assad's traditional bastion, the Alawite coastal regions.

Syria was also a location for Iran’s oil sales amid global sanctions, allowing the Islamic Republic to circumvent the crippling economic grip imposed by the US and other nations.

"This engagement is key to stabilize ties and avoiding further regional tensions," the official said.

The fall of the Assad government came after the unification of multiple Sunni militia forces, led by Hay'at Tahrir al Sham, a former al Qaeda ally.

However, it is led by Muhammad al Jolani who, though a Sunni, is known to share Iran's hatred of Israel. His grandfather was displaced to Syria from the now Israeli occupied Golan Heights in 1967.

In a rare Western media interview in 2021 with PBS Frontline, he said he was radicalized by the second intifada in 2000, one of the bloodiest periods in the Palestine-Israel conflict.

Just like Iran's backing of Gaza-based Hamas, the alliance would not be the first time Iran had aligned with Sunni militants in a bid to erase its archenemy, Israel.

“I was 17 or 18 years old at the time, and I started thinking about how I could fulfil my duties, defending a people who are oppressed by occupiers and invaders,” he said at the time.

It is not only Iran which is worried about the new transition, in spite of the global relief of the fall of a man known as a brutal dictator, and whose rule saw the deaths of at least 300,000 civilians, including hundreds in a chemical weapons attack in 2013.

The US carried out dozens of targeted airstrikes on ISIS members and facilities as fears of a resurgence of extremism remained a priority.

“There should be no doubt – we will not allow ISIS to reconstitute and take advantage of the current situation in Syria,” CENTCOM Commander General Michael Erik Kurilla said in a statement.

“All organizations in Syria should know that we will hold them accountable if they partner with or support ISIS in any way.”